4 aminoquinoline drugs?

Johnpaul Deckow asked a question: 4 aminoquinoline drugs?
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Date created: Thu, Mar 11, 2021 5:23 PM
Date updated: Sun, Aug 14, 2022 9:48 PM


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4 Aminoquinoline

  • In Vitro.
  • Mefloquine.
  • Quinine.
  • IC50.
  • Amodiaquine.
  • Chloroquine.
  • Hydroxychloroquine.
  • Antimalarial Agent.

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The search for newer 4-aminoquinoline drugs received a new dimension when Burckhalter et al. [13] discovered the antimalarial activity with some α-dialkylamino-o-cresols of the type 6 and 7. Consequently these authors prepared a large variety of Mannich bases attached to the 7-chloroquinolin-4-y1 function through a nitrogen bridge [13].

4-Aminoquinoline is a form of aminoquinoline with the amino group at the 4-position of the quinoline.The compound has been used as a precursor for the synthesis of its derivatives. A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. Examples include amodiaquine, chloroquine, and hydroxychloroquine.

4-Aminoquinoline | C9H8N2 | CID 68476 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...

The mechanism of action of 4-aminoquinolines is characterized by the concentration of the drug in the digestive vacuole of the intraerythrocytic parasite. Various hypotheses have been advanced to explain the specificity of action on the parasite; the most recent one is the inhibition of the haem polymerase of the parasite, leading to the ...

The structure of 4-aminoquinoline, of which 4-aminoquinoline antimalarial are based. In 1934 the drug chloroquine was synthesised for the first time (Cook & Zumla, 2009), which became first in class of the quinine-based drugs termed the 4-aminoquinolines. The structure of 4-aminoquinoline (Figure 1) is based on the

Most of the people (90%) used the 4-aminoquinoline antimalarials to treat an attack of malaria fever; 23% take them for prophylaxis and 7% in the population used the drugs for nonmalarial ailments. The misuse of the drugs for nonmalarial ailments may be related to their potency in treating malaria.

The 4-aminoquinoline compounds. Quinine and its chemical analogs, chloroquine (CQ) and hydroxychloroquine (HCQ), are part of the 4-aminoquinoline family of compounds ( Fig. 1 ). Despite the practical use of CQ during the Spanish flu, the antiviral effects of this drug (also known as quinine sulfate) have remained unaddressed for a long time.

Drug designed of Chloroquine as prototype drug • It consists of 4- aminoquinoline pharmacophore. • The structural analogues of chloroquine have been designed in such a way that it will show more drug likeness score than the prototype molecule but having the same pharmacophore essential for the antimalarial activity.

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