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New drug cuts the risk of death in bladder cancer by 30% compared with chemotherapy, study suggests. A trial comparing new antibody-drug conjugate enfortumab vedotin with chemotherapy in patients with bladder cancer has found that overall survival was longer in the group receiving the new drug.
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Drs. Andrew Hsieh (left) and Sujata Jana (right) found that blocking protein synthesis slows bladder tumor development and progression in lab studies. Image courtesy of Drs. Andrew Hsieh and Sujata Jana. Reining in protein production could have therapeutic effects on bladder tumors, according to new work published today in the journal JCI Insight.
The Food and Drug Administration (FDA) in recent weeks has approved four immunotherapy drugs for bladder cancer, bringing the total number of approved immunotherapies for this disease to five. Known as checkpoint inhibitors, all four drugs work by “releasing the brakes” on the immune system and allowing immune cells to attack tumors.
In December 2019, Padcev received accelerated approval from the US FDA for the treatment of patients with locally advanced or metastatic urothelial cancer (UC, the most common type of bladder cancer), specifically: Has received a PD-1/L1 inhibition in the past Patients who have received a platinum-based chemotherapy regimen before or after surgery (neoadjuvant) or after surgery (adjuvant) or in the treatment of locally advanced or metastatic disease.
An international team of scientists has been trialling a drug to block PD-L1, produced by the company Roche, on 68 people with advanced bladder cancer. All the patients had tried chemotherapy and...
Bevacizumab Does Not Provide a Survival Benefit in Metastatic Bladder Cancer Publish Date June 30, 2021 There was a significant improvement in progression-free survival with bevacizumab, but it ...
A notable new FDA approval in December 2019 was enfortumab vedotin (Padcev), approved for advanced bladder cancer patients who have not responded to chemotherapy or immune checkpoint drugs. In clinical testing, this antibody-drug conjugate produced responses in 44% of patients who failed to benefit from chemotherapy or immune checkpoint drugs.
Using a new approach to molecular drug design, scientists have created a highly promising bladder cancer treatment. The new drug to treat bladder cancer was developed by a group of researchers from Trinity College Dublin, Charles University and Motol Hospital (Prague), Lund University, and start-up company Hamlet Pharma.When used in clinical trials, the drug was found to induce rapid shedding ...
This page lists cancer drugs approved by the Food and Drug Administration (FDA) for bladder cancer. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries. There may be drugs used in bladder cancer that are not listed here.
Science News FDA Approves Trodelvy for Advanced Bladder Cancer. The antibody-drug conjugate shrank tumors in 28% of people with locally advanced or metastatic urothelial cancer. April 21, 2021 • By Liz Highleyman
Dec. 18, 2019 — Saccharin received a bad rap after studies in the 1970s linked consumption of large amounts of the artificial sweetener to bladder cancer in laboratory rats. Later, research ...