Video answer: Drugs causing qt prolongation. mnemonic
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Drugs Causing QT Prolongation
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QT . Drug–drug interactions also lead to QT prolongation. Quetiapine . Proposed — QT : Risperidone . Proposed — QT . Sudden death reported in PI. Ziprasidone Definite — QT Cancer chemotherapeutic agents Arsenic trioxide . Definite — QT, TdP : Tamoxifen . Probable — QT . Overdose situations. Cardiovascular non-anti-arrhythmics Indapamide . Proposed
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The BNF 80 (September 2020 – March 2021) lists the following examples of drugs which prolong the QT interval (note this list is not exhaustive, and not all drugs are included within the Devon Formulary): Amifampridine. Clarithromycin.
–Certain antiarrhythmic drugs prolong QT –Drug withdrawals due to QT risk (terfenadine, cisapride) for non-antiarrhythmic drugs
QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system. Pharmacoepidemiol Drug Saf. 2005;14:747-753. Indik JH, Pearson EC, Fried K, Woosley RL. Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval.
Drugs that prolong the QT interval Drugs Category Antihistamines Anti-i nfectives Antineoplastics Anti arrhythmics Antilipemic agents Calcium channel blockers Diuretics Gastrointestinal agents Hormones Antidepressants Antipsychotic Astemizole, terfenadine
QT Prolonging Drugs-Alternatives Below is a list of alternatives to some QT prolonging drugs. All patients with Long QT syndrome should speak to a health care provider or pharmacist prior to taking any new over-the-counter or prescription drug. Any questions or concerns can be directed to the BC Inherited Arrhythmia Program during regular
2. Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350:1013-1022. 3. Yap YG, Camm AJ. Drug induced QT prolongation and torsades de pointes. Heart. 2003;89:1363-1372. 4. Darpo B. Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes. Eur Heart J Supplements. 2001;3(suppl K):S70-S80. 5.
Other drugs that prolong the QT interval and have been implicated in cases of torsade include phenothiazines, tricyclic antidepressants, lithium carbonate, ziprasidone, [ 4] cisapride, highly...
Drugs to Avoid in Congenital Long QT Syndrome (cLQTS) - These drugs pose a high risk of TdP for patients with cLQTS and include all those in the above three categories (KR, PR & CR) PLUS additional drugs that do not prolong the QT interval per se but which have a Special Risk (SR) because of their other actions.