Grapefruit and drugs?

Julio Graham asked a question: Grapefruit and drugs?
Asked By: Julio Graham
Date created: Tue, Apr 27, 2021 2:56 AM
Date updated: Tue, Nov 22, 2022 9:49 AM


Video answer: Grapefruit and prescription drugs | top stories | cbc

Grapefruit and prescription drugs | top stories | cbc

Top best answers to the question «Grapefruit and drugs»

Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. Grapefruit juice can block the action of CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. The result: too much drug in your body.

Video answer: Grapefruit linked to medication overdoses

Grapefruit linked to medication overdoses

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Here are examples of some types of drugs that grapefruit juice can cause problems with (interact): Some statin drugs to lower cholesterol, such as Zocor (simvastatin) and Lipitor (atorvastatin). Some drugs that treat high blood pressure, such as Procardia and Adalat CC (both nifedipine). Some ...

Examples of some of the most common grapefruit or grapefruit juice drug interactions that can occur include: aliskiren (Tekturna) - also apple juice, orange juice alprazolam (Xanax) amiodarone (Pacerone) atorvastatin (Lipitor) carbamazepine (Tegretol) cilostazol (Pletal) clarithromycin (Biaxin) ...

A few erectile dysfunction and prostate medications deserve attention regarding grapefruit interactions: Sildenafil (Viagra) Tadalafil (Cialis) Tamsulosin (Flomax) Silodosin (Rapaflo)

Grapefruit and certain other citrus fruits, such as Seville oranges, can interfere with several kinds of prescription medications. Don't take these interactions lightly. Some can cause potentially dangerous health problems.

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits. A 2005 medical review advised patients to avoid all citrus juices until further research clarifies the risks. It

One study showed that drinking a glass of grapefruit juice with simvastatin or lovastatin increased blood levels of these statins by 260%. Summary: Grapefruit can increase the side effects of some statin cholesterol medications, causing muscle damage. Read More.

Grapefruit interactions can be dangerous because blood levels of an interacting drug may rise, potentially leading to side effects. Drug levels rise because grapefruit compounds known as furanocoumarins can block cytochrome P450 3A4 (CYP3A4) enzymes.

Statins are medicines that lower your cholesterol. Grapefruit or grapefruit juice affects some statins. Do not drink grapefruit juice if you're taking simvastatin. Grapefruit juice increases the level of simvastatin in your blood and makes side effects more likely.

Many medications can be potentiated by grapefruit juice or grapefruit. Some of the more common medications include: Some calcium channel blockers that treat high blood pressure or angina, like Procardia (nifedipine) or Plendil (felodipine)

Grapefruit and grapefruit juice can interact with some cholesterol medications, most notably, statins. That’s because these drugs metabolize in the gut, via a certain enzyme called CYP3A. Grapefruit contains compounds that inhibit this enzyme. That makes the drug more powerful than it is intended to be (1).

Grapefruit juice inhibits CYP3A4, the cytochrome P450 isoenzyme most often involved in drug metabolism. This increases plasma concentrations of the drugs concerned, creating a risk of overdose and dose-dependent adverse effects.

Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin. Bailey DG, Arnold JM, Munoz C, Spence JD. Bailey DG, et al. Clin Pharmacol Ther. 1993 Jun;53(6):637-42. doi: 10.1038/clpt.1993.84.

Grapefruit seed extract is not the equivalent of grapefruit juice, and it is not known whether extracts of grapefruit seed also have potential to alter drug metabolism. Grapefruit may interact with medications via mechanisms including inhibition of CYP3A4, CYP1A2, CYP2A6, P-gp, ATP-binding cassette drug transporters, and uptake transporters such as OATPs.

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Video answer: Drug interactions: part 2 ~ statins and grapefruit juice

Drug interactions: part 2 ~ statins and grapefruit juice