Mechanism of drug resistance?

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Amber Rice asked a question: Mechanism of drug resistance?
Asked By: Amber Rice
Date created: Wed, Jun 23, 2021 12:31 AM
Date updated: Mon, Sep 19, 2022 6:05 AM

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Mechanisms of drug resistance

  • Executive Summary. Mechanisms of Antibiotic Resistance. Resistance to antibiotics can be caused by four general mechanisms (inactivation, alteration of the target, circumvention of the target pathway or efflux of the antibiotic) and bacteria can develop resistance by mutating existing genes, or by acquiring new genes from other strains or species.

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Drug Resistance Mechanisms for Drug Resistance. There are several common mechanisms for drug resistance, which are summarized in Figure... Multidrug-Resistant Microbes and Cross Resistance. From a clinical perspective, our greatest concerns are... Methicillin-Resistant Staphylococcus aureus (MRSA)…

Santosh Yadav Definition :- Drug resistance (Antimicrobial resistance) is the reduction in effectiveness of a drug in curing a disease. When the drug is not intended to kill or inhibit a pathogen, then the term is equivalent to dosage failure or drug tolerance. Antibiotic resistance is the ability of bacteria to resist the effect of an antibiotics, i.e. the bacteria is not killed or their growth is not stopped. Resistance bacteria survive exposure to the antibiotics and continue to multiply ...

In general, mutations resulting in antimicrobial resistance alter the antibiotic action via one of the following mechanisms, i) modifications of the antimicrobial target (decreasing the affinity for the drug, see below), i) a decrease in the drug uptake, ii) activation of efflux mechanisms to extrude the harmful molecule, or iv) global changes in important metabolic pathways via modulation of regulatory networks. Thus, resistance arising due to acquired mutational changes is diverse and ...

Mechanism of Drug Resistance. An organism may become resistant to a drug through various mechanisms. Prominent among these is the production of enzymes to destroy the drug. Microbes i.e. bacteria ...

The main mechanisms of resistance are: limiting uptake of a drug, modification of a drug ...

Another mechanism of drug resistance involves expressing higher levels of the target. This can be accomplished either through increased transcription and translation or gene amplification. This results in a requirement for higher levels of drugs to achieve the same level of inhibition.

Resistance mechanisms highlighted in this review include: 1. Decrease of drug uptake because of the loss of a transporter required for uptake. This decrease contributes to resistance to arsenicals and diamidines in African trypanosomes. 2. The export of drugs from the parasite by P-glycoproteins and other traffic ATPases.

The three fundamental mechanisms of antimicrobial resistance are (1) enzymatic degradation of antibacterial drugs, (2) alteration of bacterial proteins that are antimicrobial targets, and (3) changes in membrane permeability to antibiotics. Antibiotic resistance can be either plasmid mediated or maintained on the bacterial chromosome.

The most common mechanism of resistance is production of neutralizing enzymes by bacteria Genes encoding betalactamases may be present on chromosome or plasmid. These genes may be constitutively expressed or induced by a beta-lactam antibiotic. Such form of resistance is seen in S.aureus, H.influenzae, E.coli, K.pneumoniae etc.

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