Oestrogen suppression drugs?

Hipolito Leuschke asked a question: Oestrogen suppression drugs?
Asked By: Hipolito Leuschke
Date created: Wed, Jun 9, 2021 6:48 AM
Date updated: Thu, Nov 24, 2022 8:48 PM


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Top best answers to the question «Oestrogen suppression drugs»

Medications that stop the body from making estrogen after menopause

  • Anastrozole (Arimidex). Anastrozole is used to reduce the risk of cancer recurrence in women who have been treated for early-stage breast cancer…
  • Exemestane (Aromasin)…
  • Letrozole (Femara).

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Oestrogen-suppressing drugs substantially reduce breast cancer deaths. A class of hormonal drugs called aromatase inhibitors substantially reduce the risk of death in postmenopausal women with the most common type of breast cancer, a major study of more than 30,000 women shows.

Aromatase inhibitors suppress the synthesis of oestrogens and are taken by postmenopausal women with hormone-sensitive (ER-positive) breast cancer. They have previously been reported to reduce the...

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic properties in young healthy males.

Drugs to stop the ovaries making oestrogen (ovarian suppression) Goserelin (Zoladex ®) is a drug that stops the ovaries making oestrogen and causes a temporary menopause. You may have goserelin on its own or with tamoxifen or an AI. Your specialist nurse will give you goserelin as a monthly injection under the skin of the tummy (abdomen).

Two classes of drugs are used for hormone therapy: selective estrogen receptor modulators (SERMs) such as tamoxifen and aromatase inhibitors (AIs). 4  These are given based on your menopausal status and your breast cancer diagnosis. A SERM or an aromatase inhibitor may be used with or without ovarian suppression therapy.

Selective estrogen receptor modulators, which block hormones from attaching to cancer cells. Tamoxifen, which was introduced in the 1960s, is the most common example of SERMs. Aromatase inhibitors...

Estrogens may be used to treat symptoms of conditions associated with estrogen deficiency such as amenorrhea and menopause. They may be used to suppress lactation and in men to treat androgen-dependent cancers such as prostate cancer.

Common LHRH drugs include goserelin (Zoladex) and leuprolide (Lupron). They can be used alone or with other hormone drugs (tamoxifen, aromatase inhibitors, fulvestrant) as hormone therapy in pre-menopausal women. Chemotherapy drugs: Some chemo drugs can damage the ovaries of pre-menopausal women so they no longer make estrogen. Ovarian function can return months or years later in some women, but in others the damage to the ovaries is permanent and leads to menopause.

What are Aromatase inhibitors? Aromatase inhibitors are a class of medicines that work by blocking the enzyme aromatase, the enzyme that converts androgens into estrogen. Aromatase inhibitors are used in the treatment of breast cancer to reduce levels of circulating estrogen.

Most types of hormone therapy for breast cancer, like selective estrogen-receptor modulators or aromatase inhibitors, either lower estrogen levels or stop estrogen from acting on breast cancer cells. 4 This kind of treatment is helpful for hormone receptor-positive breast cancers, but it does not help patients whose tumors are hormone receptor negative (both estrogen-receptor and progesterone-receptor-negative).

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