Protein and peptide drug delivery?

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Dane Dach asked a question: Protein and peptide drug delivery?
Asked By: Dane Dach
Date created: Thu, Jul 8, 2021 1:24 PM
Date updated: Wed, Aug 24, 2022 10:59 PM

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Top best answers to the question «Protein and peptide drug delivery»

  • Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes, hormones, structural element and immunoglobulin.

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Protein and Peptide drug delivery: oral approaches Till recent, injections remained the most common means for administering therapeutic proteins and peptides because of their poor oral bioavailability.

Designing and formulating a protein and peptide drug for delivery though GI tract requires a multitude of strategies. The dosage form must initially stabilize the drug making it easy to take orally4. It must then protect the drug from the extreme acidity and action of pepsin in the stomach.

Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes,...

Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Recent advancements in the proteomics and recombinant DNA technology, by enabling identification of distinct structural feat …

Most of these approaches mainly focus on the delivery of proteins and peptides by the oral route, as it is the most popular method of drug administration among patients because of its simplicity.

Peptides and proteins are complex architecture therapeutics useful in several diseases. Several pharmaceutical and biopharmaceutical challenges limit their clinical applications. Continuous efforts are focussed for formulation of this therapeutics into safe and effective delivery systems.

Parenterals are an orthodox choice for this which has some drawback related to patient acquiescence and formulation. The evolution of new macromolecule drugs, i.e. proteins and peptides can be...

Number of approaches are available for effective protein and peptide drug delivery.  They are  IONTOPHORESIS  PHONOPHORESIS  PENETRATION ENHANCERS  PRODRUG  Iontophoresis: Used for local and systemic delivery of proteins and peptides. In this an electric current is used to drive the molecules across the skin surface.

Engineering protein and peptide-based materials for drug delivery applications has gained momentum due to their biochemical and biophysical properties over synthetic materials, including biocompatibility, ease of synthesis and purification, tunability, scalability, and lack of toxicity.

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