Pulmonary excretion of drugs?

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Kiley Luettgen asked a question: Pulmonary excretion of drugs?
Asked By: Kiley Luettgen
Date created: Fri, Jan 8, 2021 12:19 PM
Date updated: Mon, Sep 12, 2022 9:37 PM

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Video answer: Pulmonary and salivary excretion

Pulmonary and salivary excretion

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PULMONARY EXCRETION

Gaseous and volatile substances such as general anesthetics (Halothane) are absorbed through lungs by simple diffusion. Pulmonary blood flow, rate of respiration and solubility of substance effect PE. Intact gaseous drugs are excreted but not metabolites.

Video answer: Pulmonary and skin excretion of drugs: non renal route of excretion. english & hindi. dr. srikanth.

Pulmonary and skin excretion of drugs: non renal route of excretion. english & hindi. dr. srikanth.

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Pulmonary excretion is a primary route for the elimination of gases and some volatile compounds. Elimination of drugs by breast milk is important, not because of any quantitative significance, but because it represents a potential danger to the nursing infant. Drugs of particular concern include lithium, various anticancer agents, and isoniazid.

The rate of loss of gases is not constant; it depends on the rate of respiration and pulmonary blood flow. The degree of solubility of a gas in blood also will af-fect the rate of gas loss. Gases such as nitrous oxide, which are not very soluble in blood, will be excreted rapidly, that is, almost at the rate at which the blood de-livers the drug to the lungs.

Biliary excretion of drugs Recall from histology that mixed blood from the portal vein and hepatic artery flows in the hepatic sinusoids into the central vein. Hepatocytes and endothelial cells face these sinusoids.

In describing pulmonary uptake, several terms are used. The expression ‘pulmonary uptake’ is reserved for the process of transfer of a drug from the blood into the lungs, regardless of subsequent metabolism or release back into the blood. ‘Extraction’ is often used as a synonym of ‘uptake’.

Drug Excretion. Drug excretion is the final step in the ADME (Absorption, Distribution, Metabolism, and Excretion) process and consists of a series of pathways that remove an administered drug and/or its metabolites from the body. From: Reference Module in Biomedical Sciences, 2021. Related terms: Metabolic Pathway; Drug Metabolism; P-Glycoprotein; Nested Gene

The biliary system contributes to excretion to the degree that drug is not reabsorbed from the gastrointestinal (GI) tract. Generally, the contribution of intestine, saliva, sweat, breast milk, and lungs to excretion is small, except for exhalation of volatile anesthetics.

RENAL EXCRETION Kidney is the primary organ of removal for most drugs especially for those that are water soluble and not volatile. The three principal processes that determine the urinary excretion of a drug1.glomerular filtration,2. tubular secretion, and3.tubular reabsorption (mostly passive back- diffusion)

When the concentration of the drug in the body is high, the secretory transport carriers can become saturated and the excretion reaches an upper limit. Drugs that are excreted through bile are...

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