Qt interval drugs to avoid?

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Jacey Gorczany asked a question: Qt interval drugs to avoid?
Asked By: Jacey Gorczany
Date created: Tue, Apr 6, 2021 8:52 AM
Date updated: Mon, Dec 5, 2022 5:05 AM

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Video answer: Stanford hospitals and clinics: faq: medications for long qt syndrome

Stanford hospitals and clinics: faq: medications for long qt syndrome

Top best answers to the question «Qt interval drugs to avoid»

Table 1

Drugs to be avoided in patients with c-long QT syndrome
ClassGeneric name
AnestheticSevoflurane
Anti-anginalRanolazine, Bepridil
Anti-arrhythmicSotalol, Quinidine, Amiodarone, Ibutilide, Disopyramide, Procainamide, Flecainide, Dofetilide, Dronedarone

Video answer: Drugs increase qt interval || proarrhythmic agents

Drugs increase qt interval || proarrhythmic agents

10 other answers

Few authors verified the utility of different drugs to prevent lengthening of QTc interval associated to intubation: Owczuk et al demonstrated that the use of intravenous lidocaine (1.5 mg/kg) before laryngoscopy and intubation prevented prolongation of the QTc interval induced by the maneuver. Therefore, it seems useful the association of midazolam in premedication and lidocaine before intubation.

There is substantial evidence that nelfinavir is associated with TdP when taken with other medicines that prolong the QT interval or drugs that block the metabolic breakdown of nelfinavir. Ivabradine (Procoralan®, Coralan®, Corlentor®, Coraxan®, Ivabid®, Bradia®) is a medicine approved in many countries o utside the US for treatment of angina pectoris (heart pain).

Drugs which people with Long QT Syndrome should avoid Aclarubicin. Adrenaline (Epinephrine). Ajmaline*. Alfuzosin. Almokalant*. Amantidine. Amiodarone. Amitriptyline. Amoxapine*. Amphetamine. Amsacrine. Arsenic trioxide. Astemizole*. Atomoxetine. Azelastine. Azimilide*. Azithromycin…

Following are the drugs which should be avoided by a patient suffering from long QT syndrome as they may aggravate the condition. Advertisement Anti-arrhythmic drugs: These drugs are used to manage arrhythmia, but they may also cause the prolongation in QT interval.

A long QT interval is most frequently seen with class I and class III antiarrhythmic drugs. Other classes of drugs that cause QT c prolongation include antihistamines, antidepressants, antibiotics, antifungal drugs and antipsychotics . The prolongation of the QT c interval by these drugs is usually seen within several days of starting them. The class Ia antiarrhythmic drugs (quinidine, procainamide) and class III drugs (sotalol, amiodarone) prolong the repolarisation phase of the cardiac ...

All of the above medicines and the asthma medicines Fenoterol and the inhaled bronchod lator/cothcosteroid combination Salmeterolfflutlcasone, were added to the Drugs to Avoid in congenital Long QT syndrome (cLQT S) category. We welcome your feedback and suggestions for how CredibleMeds can better serve your need for information about medicines

In general, manufacturers advise that the use of two or more drugs that are associated with QT prolongation should be avoided. Increasing age, female sex, cardiac disease and some metabolic disorders (notably hypokalaemia) predispose to QT prolongation. Prescribers should also use caution when prescribing concurrent drugs that reduce serum potassium.

Drugs to Avoid in Congenital Long QT Syndrome (cLQTS) - These drugs pose a high risk of TdP for patients with cLQTS and include all those in the above three categories (KR, PR & CR) PLUS additional drugs that do not prolong the QT interval per se but which have a Special Risk (SR) because of their other actions.

a QT prolonging drug • Current use of any non-cardiac QT prolonging drug was associated with a significantly increased risk of SCD (adjusted OR 2.7) • The highest risk was associated with antipsychotic drugs (adjusted OR 5.0). • The risk was higher in women and in people who had recently started a QT prolonging drug

The UK Medicines and Healthcare products Regulatory Agency (MHRA) has released warnings relating to drug-induced QT prolongation for many commonly used drugs, such as citalopram, domperidone, ondansetron and quinine. 29–32 From a practical perspective, data are inconclusive with regard to arrhythmic risk for drugs that increase the QTc interval by <20 ms; drugs associated with a change in baseline QTc of >20 ms should raise concern. 33 For example, haloperidol prolongs the QT interval by ...

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Video answer: Long qt syndrome and torsades - an osmosis preview

Long qt syndrome and torsades - an osmosis preview