Quinoline drugs?

Grady Crona asked a question: Quinoline drugs?
Asked By: Grady Crona
Date created: Mon, Mar 15, 2021 2:13 PM
Date updated: Tue, Nov 8, 2022 11:43 AM


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Indole and quinoline alkaloids | how they are derived

Top best answers to the question «Quinoline drugs»

Quinoline-based antimalarial compounds, such as CQ, hydroxychloroquine (HCQ), quinine (QN), mefloquine (MFQ), and quinacrine (QNX), are mainstay therapies that effectively kill P. falciparum parasites. Chloroquine, a commonly prescribed QBA that harbors weakly basic properties, traverses erythrocyte and P.

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Quinolones are a type of antibiotic. Antibiotics kill or inhibit the growth of bacteria. There are five different quinolone classes. In addition, another class of antibiotic, called fluoroquinolones, were derived from quinolones by modifying their structure with fluorine.

Antimalarial quinolines are used to prevent and treat malaria. During the blood stages of the life cycle of malaria parasite the parasite needs to degrade hemoglobin. Hemoglobin digestion releases free heme that is toxic to the parasite, so it is then polymerised to non toxic hemozoin.

Quinoline-containing antimalarial drugs, such as chloroquine, quinine and mefloquine, are mainstays of chemotherapy against malaria. The molecular basis of the action of these drugs is not completely understood, but they are thought to interfere with hemoglobin digestion in the blood stages of the malaria parasite's life cycle.

Salmo gairdneri (rainbow trout) readily absorb & metabolize (14)C quinoline when exposed to 1 mg/l concn in water.Juvenile fish accumulated over 60% of the total radiolabel body burden in the gall bladder as quinoline metabolites after 48 hr exposure, followed by 24 hr in clean water.Hydrolysis products of the metabolites, isolated by alkaline digestion & base-catalysed acetylation, were found to be hydroxyquinolines & quinolinethiols.

Areas covered: Quinoline drugs that are currently approved or under clinical investigation were reviewed based on a literature search. Their modes of action and outcomes during clinical research are discussed. Expert opinion: Undoubtedly, quinoline-based compounds have a significant impact on anticancer drugs. Although topoisomerase and kinase inhibitors are the only two different classes of agents that are currently approved for anticancer therapy, more than twenty different drug candidates ...

The antimalarial drugs chloroquine, mefloquine, and amodiaquin are synthetic quinoline compounds, as are dibucaine hydrochloride, a long-acting local anesthetic that is commonly used as a topical agent to relieve pain from minor cuts and insect bites and stings, and cyanine, the oldest of an important class of dyes.

Further evaluation of this drug library identified eight protective drugs that shared a common quinoline scaffold. These drugs were tested further in terms of their protection against other aminoglycosides, as well as their effect on aminoglycoside uptake.

The quinoline-containing antimalarial drugs, chloroquine, quinine and mefloquine, are a vital part of our chemotherapeutic armoury against malaria. These drugs are thought to act by interfering with the digestion of haemoglobin in the blood stages of the malaria life cycle.

The Quinism Foundation is a 501 (c) (3) nonprofit charitable organization established January 1, 2018 in White River Junction, Vermont. The Quinism Foundation promotes and supports education and research on quinism, the medical disorder caused by poisoning by mefloquine, tafenoquine, chloroquine, and related quinoline drugs.

Quinoline is a heterocyclic aromatic organic compound with the chemical formula C 9 H 7 N. It is a colorless hygroscopic liquid with a strong odor. Aged samples, especially if exposed to light, become yellow and later brown. Quinoline is only slightly soluble in cold water but dissolves readily in hot water and most organic solvents.

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