Top best answers to the question «Ranolazine drug class»
Ranolazine is used alone or with other medications to treat chronic angina (ongoing chest pain or pressure that is felt when the heart does not get enough oxygen). Ranolazine is in a class of medications called anti-anginals.
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Many drugs can affect ranolazine, especially: any other medicine to treat heart disease; an antibiotic or antifungal medicine; cholesterol-lowering medicine; oral diabetes medicine; medicine to prevent organ transplant rejection; medicine to treat a mental illness; or medicine to treat or prevent ...
Ranolazine, sold under the brand name Ranexa among others, is a medication used to treat heart related chest pain. Typically it is used together with other medications when those are insufficient. Benefits appear smaller in women than men. It is taken by mouth. Common side effects include constipation, headache, nausea, and dizziness. Serious side effects may include QT prolongation. Use is not recommended in those with liver cirrhosis. How it works is not clear but may involve adenosine triphos
Hazardous Substances Data Bank (HSDB) Ranolazine is contraindicated in patients with clinically significant hepatic impairment. Plasma concentrations of ranolazine were increased by 30% in patients with mild (Child-Pugh Class A) and by 60% in patients with moderate (Child-Pugh Class B) hepatic impairment.
Ranolazine is indicated for the treatment of chronic angina. It can be used alone or in conjunction with nitrates, beta-blockers, angiotensin receptor blockers, anti-platelet drugs, calcium channel blockers, lipid-lowering drugs, and ACE inhibitors. 17.
• Acute coronary syndrome: Ranolazine will not relieve acute angina episode and has not demonstrated benefit in acute coronary syndrome. • Hepatic impairment: Ranolazine plasma levels increase by 30% in patients with mild (Child-Pugh class A) and by 80% in patients with moderate (Child-Pugh class B) hepatic impairment.
Ranolazine is extensively metabolized to numerous metabolites, and has potential for multiple and complex cytochrome (CYP) P450 drug interactions (see Drug Interactions). Ranolazine is also associated with potential for drug interactions based on its propensity to prolong the QT interval.
Contraindicated for all degrees of hepatic impairment in patients with liver cirrhosis; ranolazine reported to increase 80% in cirrhotic patients with moderate (Child-Pugh Class B) hepatic...
Ranolazine (Ranexa) represents a new class of drugs known as metabolic modulators. It is labeled for use in combination with amlodipine (Norvasc), beta blockers, or nitrates in patients with...